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心脑血管疾病患者血清Hcy与血脂检查分析论文

日期:2017-6-5作者:无忧论文网编辑:yoyoma点击次数:155
销售价格:150元论文编号:lw201706021657475110论文字数:3920 
论文属性:职称论文论文地区:中国论文语种:中文 

摘要


目的:探讨心脑血管疾病患者血清同型半胱氨酸(Hcy)与血脂检查的的关系及临床意义。方法:选择2013年3月~2014年3月我院收治的高血压病患者心脑血管疾病患者160例(心脑血管疾病组)及同期40例健康体检者作为对照组。检测并比较两组研究对象的Hcy及相关血脂指标差异,并根据各种疾病类型将心脑血管疾病组患者分为单纯高血压组、高血压糖尿病组、高血压冠心病组和高血压脑梗死组进行分层分析。结果:心脑血管疾病组的Hcy 16.22±2.5(μmol)、TC 3.97±0.94(mmol)、LP(a)258.7±16.4(mg/L)、ApoA1142.6±10.5(mg/dl)、ApoB102.6±18.4(mg/dl)测定值均显著高于对照组患者(P<0.05);两组患者的TG、HDL-C、LDL-C测定值比较差异均不具有统计学意义(P<0.05)。单纯高血压组、高血压糖尿病组、高血压冠心病组、高血压脑梗死组的Hcy 、TC 、HDL-C、LP(a)、ApoB测定值比较差异具有统计学意义(P<0.05);四组间TG、LDL-C、ApoA1测定值比较差异均不具有统计学意义(P>0.05);组间两两比较:单纯高血压组的Hcy、TC 、HDL-C、ApoB测定值与高血压脑梗死组比较差异有统计学意义(P<0.05)。结论:心脑血管疾病患者中Hcy、TC、LP(a)、ApoA1、ApoB指标与正常人群差异均显著,同时不同类型的心脑血管疾病患者的Hcy 、TC 、HDL-C、LP(a)、ApoB测定值存在差异。


Abstract


Objective: To investigate the serum level of homocysteine in patients with cardiovascular and cerebrovascular diseases (Hcy) and blood lipid examination of the relationship and clinical significance. Methods:Select March 2013 - March 2014 in our hospital, 40 patients with essential hypertension in patients with cardiovascular disease 160 cases (hypertension group), 40 patients with hypertension and coronary heart disease (CHD hypertension), high blood pressure 40 patients with diabetes (diabetic hypertensive group), 40 patients with cerebral infarction hypertension (high blood pressure cerebral infarction group) (cardiovascular disease group) and 40 healthy volunteers over the same period as the control group. Detected and compared four groups of Hcy and related subjects differences in lipid levels, and according to the type of the group of patients with various diseases, cardiovascular diseases are divided into simple hypertension, diabetes, hypertension group, hypertension, coronary heart disease and hypertension group brain infarction stratified analysis.Results: Cardiovascular disease group Hcy 16.22 ± 2.5 (μmol), TC 3.97 ± 0.94 (mmol), LP (a) 258.7 ± 16.4 (mg / L), ApoA1142.6 ± 10.5 (mg / dl), ApoB102.6 ± 18.4 (mg / dl) were significantly higher than the measured values of patients (P <0.05); the two groups of patients with TG, HDL-C, LDL-C measurements compare the differences were not statistically significant (P <0.05). Simple hypertension, diabetes, hypertension group, hypertension, coronary heart disease group, Hcy hypertensive cerebral infarction group, TC, HDL-C, LP (a), ApoB measured values and the difference was statistically significant (P <0.05); four groups TG, LDL-C, ApoA1 measured value differences are not statistically significant (P> 0.05); between any two groups: Hcy hypertensive group, TC, HDL-C, ApoB measurements with high blood pressure and cerebral infarction group difference was statistically significant (P <0.05).Conclusion:Patients with cardiovascular disease Hcy, TC, LP (a), ApoA1, ApoB indicators normal population differ significantly, while different types of cardiovascular disease in patients with Hcy, TC, HDL-C, LP (a), ApoB differences in measured values. 


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