儿童精神分裂症患者脑脊液中氨基酸神经递质的测定
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字数: 2,317
编号: 50
类别: 医学〉临床医学
级别: 学术论文
郭沈昌 柯小燕 谭钊安 李振国 王 键 罗硕军 金利波
【摘要】
目的 探讨儿童精神分裂症可能的发病机制。
方法 采用反向高效液相色谱法测定16例儿童精神分裂症患儿（患儿组）和11例患阑尾炎的患儿（对照组）脑脊髓液（CSF）中谷氨酸、天门冬氨酸（兴奋性氨基酸）和甘氨酸（抑制性氨基酸）的浓度并进行比较。
结果 患儿组CSF中谷氨酸为[（9.7±3.1）μmol]，甘氨酸为[（9.7±3.7）μmol]，低于对照组[分别为（41.9±22.3）μmol和（16.1±11.8）μmol]，而天门冬氨酸含量两组差异无显著性。
结论 儿童精神分裂症的发病机制中可能有氨基酸神经递质的参与。
【关键词】精神分裂症 儿童 脑脊髓液 氨基酸类
Determination of Amino-acid Neurotrasmitte in Cerebrospinal Fluid (CSF) of Childhood Schizophrenics
GUO Shenchang,Ke Xiaoyan,Tan Zhaoan et al. The Mental Health Center Shantou University Guangdong 515063
【Abstract】Objective: To study the pathologic mecharism of childhood schizophrenics.Methods: The high-performance liquid chromatography (HPLC) of reverse was used to deteminated and compared the concentrations of glutamic-acid,aspartic-acid(excitatory amino-acid) and glycine(inhibitory amino-acid) in CSF of 16 patients with childhood schizohprenics and 11 controls of childhood appendicitis.Results: The concentrations of glutamic-acid[(9.7士3.1)μmol] and glycine[(9.7士3.7)μmol] in CSF of the patients with childhood schizophrenia were obviously lower than those[(41.9士22.3) μmol and(16.1士11.8)μmol,respectively) of controls;but there was no significantly difference of the content of aspartic-acid between two groups.Conclusions: It is probable that the amino-acids neurotrasmitter was participated in the pathologic mechanism of childhood schizophrenics..
【Key Words】 Schizophrenia Childhood Cerebrospinal fluid Amino-acids