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【关键词】血浆
摘要:目的:探讨血浆同型半胱氨酸(HCY)与高温作业致心血管病变的关系。方法:接触有害作业231名,分成4组;铅作业80名,苯作业70名,锰作业42名,高温作业39名。60名健康为对照组,检测血浆HCY水平。测量血压及心电图检查。结果:高温组血浆HCY升高心血管改变与对照组有显著性差异(p<0.01)。其余3组与对照组无显著性差异。随着年龄增长、作业工人工龄延长高HCY患病率增高。结论:高HCY可能是心血管疾病的独立危险因素,血浆HCY水平升高与高温作业致心血管疾病的发展和发生存在着密切关系。
关键词:高温作业;心血管;血浆同型半胱氨酸
Study the Relationship Between the Cardiovascular Disease Caused by the high-temperature Operation and the HCY Change
LIU Wei-ying, WANG De-wen
(The Central Hospital of Shanghai, Shanghai 200031, China)
Abstract: Objective: To investigate the relationship between the cardiovascular disease caused by the high-temperature operation and the HCY change. Method: 231 workers exposed to the toxic substance were chosen including 80 workers who have the contact with lead, 70 with benzene, 42 with manganese as well as 39 workers who work in the high temperature. They were divided into 4 groups separately to form comparison with the healthy group of 60 people. They were tested HCY level, blood pressure and electrocardiogram respectively. Result: The striking difference is found between the high-temperature group and the healthy one. And the difference mainly lies in the rise of HCY and the change of heart and blood vessels (p<0.01). However, no noticeable difference was found between the healthy group and the rest three groups. As the age advances and the length of service increases, so does the risk of suffering diseases from high HCY. Conclusion: High HCY blood pressure may be a无忧论文 【http://www.uklunwen.com】n independent risk factor for the cardiovascular disease. The rise of HCY is closely related to the development and occurrence of cardiovascular disease caused by high-temperature operation.
Key words: High-temperature operation;Cardiovascular;Homcysteine
近来研究提示血浆同型半胱氨酸(Homcysteine, HCY)是检测心脑血管疾病的指标,高HCY可能是心脑血管疾病的独立危险因素之一[1]。高HCY血症与诸多心血管疾病的关系已引起关注。在职业病调查研究中,常常要研究各种有害物质与发病的关系。本文重点探讨血浆高HCY水平与常见高温作业引起心血管改变的关系。
1 资料与方法
1.1 研究对象:依据《中华人民共和国职业病防治法》,国家颁布的《职业病目录》范围内有害作业因素,选取接触有毒有害气体作业工人231名,其中铅作业80名,苯作业70名,锰作业42名,高温作业39名。男122名,占53%,女109名,占47%。年龄20~55岁。平均(32.92 ±9.26)岁,工龄2~34年,平均工龄(12.58±5.04)年。对照组,来自厂矿,合资企业不接触任何有害作业健康查体人员,排除心脑血管疾病,糖尿病,慢性肾功能不全疾病,共60名,男35名,占58%,女25名,占42%。年龄24~55岁,平均(33.24±9.4)岁,工龄2~30年,平均工龄(13.10±5.34)年。两组人选近一月内,正常饮食,均未服影响血浆HCY药物如:氨甲喋啶,抗癫痫药物及维生素B12,叶酸等。
1.2 研究方法
1.2.1 实验室方法:血浆同型半胱氨酸测定:所有研究对象均在清晨8:00空腹抽取静脉2ml (肝素 抗凝) 30min内分离,40℃离心,置于-20℃冰柜保存,采用高效液相色谱―串联质谱方法进行测定。参考值:正常5~15 umol/L; 轻高15~30umol/L; 中高30~100umol/L;重高>100umol/L。同时检测血清中血糖、胆固醇、尿素氮、肌酐及血常规。
1.2.2 根据接触毒物种类将观察组231名分为4组;铅观察组,苯观察组,锰观察组,高温观察组与对照组比较。 血压检查采用台式血压计,使用前计量校准,经休息20min,测量坐位右臂血压,血压异常者测量三次,间隔30min,取平均值。依据WHO高血压的诊断标准进行诊断。 心电图 使用ECG-32A心电图仪进行描记,按照临床心电图标准进行诊断。
1.2.3 统计学处理:数据资料以±s 示,组间比较采用P值检验。P<0.05为有显著性差异。
2 结果
2.1 血浆同型半胱氨酸的变化
2.1.1 高温组与对照组检测的HCY值之间有显著性差异,P<0.01。苯组,铅组,锰组与对照组无显著性差异(P>0.05),见表1。
2.1.2 随着年龄增长、接触作业工龄延长,高HCY百分比越大,见表2。
2.1.3 高血浆HCY工人中,血压超标(单纯性收缩压升高)占65%,心电图异 |
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