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Hydrogels of poly[(dimethylaminoethyl methacrylate)-co- (diallyl dimethyl ammonium chloride)] as thermal and pH controlled drug delivery system for releasing notoginsenoside
Abstract
Poly [(dimethylaminoethyl methacrylate)-co-(diallyldimethyl ammonium chloride)] [poly(DMAEMA-co-DADMAC)] hydrogels were synthesized by γ induced copolymerization in order to achieve a controlled drug delivery system for notoginsenoside, the main compound extracted from panax notoginseng (PANS), a famous Chinese herb. Copolymerization of DMAEMA and DADMAC was found as an azeotropic one in our studies. The charge of PolyDADMAC (polyelectrolyte) could distribute uniformly along the macromolecular chains in poly(DMAEMA-co-DADMAC) hydrogels. The equilibrium degree of swelling (EDS) of the gels had a maximum at 3% of charge density and temperature sensitivity would not exist when charge density was approximately higher than 5%. The gels of 3% of charge density was chosen for controlled release of notoginsenoside because of its best swelling property among the gels as well as temperature and pH sensitivity. Changing temperature, pH and salt concentration of the medium could control the release of notoginsenoside. The animal experiment showed that the gels saturated with PANS showed relatively good biological compatibility and could be of function in cicatrizing the wound of rat due to the release of notoginsenoside.
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